Simplicius of Autun was a 4th-century Catholic bishop serving in Gaul. Born into a noble family, he was chosen by his fellow citizens to succeed Egemonius as the leader of the church in Autun. Although he was married, he reportedly lived in a state of chastity with his wife. Historical records regarding his exact dates of service are uncertain, as different sources place a bishop of this name at various councils throughout the 4th and early 5th centuries.