Asclepiades of Antioch was a bishop and Patriarch of Antioch who led the see from approximately 211 until his death around 217 or 218. Succeeding Serapion, he governed the church during the reign of the Roman emperor Caracalla. He is recognized as a confessor and is also titled a martyr because of the hardships he faced during periods of Roman persecution. He was followed in his office by Philetus.