Matrona of Chios was a 15th-century Greek Orthodox nun and abbess who lived on the island of Chios. Born in the village of Volissos to a prosperous Christian family, she chose a life of celibacy and monasticism over marriage. After using her inheritance to establish a monastery in the Palaiókastro district, she was elected to lead the community. She is remembered for her deep spirituality, her extensive charity toward the poor, and her ability to heal the sick.