Serena of Rome was a legendary third-century Christian martyr whose historical existence is considered doubtful. According to tradition, she was the wife of the Emperor Diocletian, though this connection remains unproven. Some accounts suggest she was cast out by her husband due to her faith, potentially leading to her martyrdom. Other traditions claim she lived in exile in Magliano Sabina. Because of her legendary status, she is no longer included in the current martyrology, despite being previously listed in the Martyrologium Romanum.