Euphemia was a 6th-century Byzantine empress who served as the consort of Emperor Justin I. Originally named Lupicina, she rose to imperial status after her husband, a former soldier, ascended the throne in Constantinople. She is frequently credited with influencing the religious and ecclesiastical policies of the empire during her husband's reign. Following her death around 523 or 524, she was interred in a church she had established, and her husband was later buried alongside her.