Anastasius II of Antioch, also called Anastasius the Younger, was a 7th-century presbyter and the Greek Patriarch of Antioch. Born in Alexandria around 600, he assumed leadership of his diocese in 599. He is primarily recognized for his vigorous efforts to suppress simony within his jurisdiction, an initiative that received backing from Pope Gregory the Great. His tenure concluded in 609 when he died in Antioch during a period of intense local unrest.