Pope Macarius III of Alexandria was the 114th Pope of the Coptic Orthodox Church, serving from his time as Metropolitan of Asyut until his death in 1945. Born in El Mahalla El Kubra, he was only the second metropolitan in the history of the Alexandrian See to ascend to the papacy. His leadership was marked by significant internal tensions between the Holy Synod and the General Congregation Council, which eventually led to his temporary exile from the capital.