Melkisedek I was a 11th-century religious leader who served as the first Catholicos-Patriarch of All Georgia. Following the unification of the Georgian kingdom, he transitioned the church leadership from the older title of Catholicos of Kartli to his new, combined designation. Based in Ani, he held his office from approximately 1010 until his death in 1033, serving under several Georgian monarchs, including Bagrat III and George I.