Margaret of Lorraine was a 15th-century French duchess who later became a nun. Born in 1463 at Vaudémont, she was the daughter of Frederick II and Yolande. After marrying René, the Duke of Alençon, in 1488, she mothered three children. Following her husband's death in 1492, she managed the duchy and oversaw her children's upbringing. She eventually entered the Poor Clares order, taking religious vows in 1520 before passing away in Argentan in 1521.