Senecas of Jerusalem was a Jewish Christian leader serving as a bishop in Jerusalem during the 2nd century. According to the historian Eusebius of Caesarea, he occupied the tenth position among thirteen bishops who led the local church in the period spanning from the destruction of the Second Temple to the Bar Kokhba revolt. His name also appears in the Epistle of James to Quadratus, linking him to the early Christian community of the region.