Gregory of Spoleto was a Christian priest living in Spoleto during the early 4th century. He was targeted by the general Flaccus, who acted under orders from Emperor Maximian to suppress Christian practices. Because he was accused of leading others away from the worship of traditional gods and emperors, he was arrested and subjected to prolonged torture. He eventually met his death by beheading on December 24, 304, during this period of imperial persecution.