Laurence of Siponto was a 6th-century presbyter and bishop who served the people of Siponto. Originally from Constantinople, he was appointed to the vacant bishopric around 491 by Emperor Zeno. During his leadership, he brought important relics to his diocese and secured imperial support to construct a church and a baptistry. He is also remembered for his purported role in negotiating with the Gothic leader Totila to protect his city.