Henry of Asti was a 14th-century Catholic prelate who served as the titular Latin patriarch of Constantinople and the bishop of Negroponte. Born in Asti around 1300, he became a prominent figure in the politics of Frankish Greece. He is most recognized for his role as the commander-in-chief of the first Smyrniote crusade. During this military campaign against the Turkish ruler Umur Beg, Henry led various naval and land forces, eventually losing his life during a religious service in İzmir in 1345.