Domenico Spadafora was a 15th-century Italian Dominican priest and evangelist known for his missionary work. Born in Randazzo to a noble family, he pursued extensive theological studies in Perugia and Padua before joining the Order of Preachers. He gained recognition for his preaching, which inspired many people to join the Dominican order and led several individuals to change their ways. He is particularly remembered for establishing and overseeing the construction of the Madonna delle Grazie convent in Monte Cerignone.