Margaret of Castello was a 13th-century Italian religious woman and educator who lived with significant physical disabilities, including blindness and a curved spine. After being abandoned by her noble parents at a shrine in Città di Castello, she was cared for by the local poor and later joined the Dominican Third Order. She dedicated her life to teaching children about the faith and providing childcare for working families. Recognized for her profound holiness, she is venerated as a saint in the Catholic Church.