Giovanni Antonio Guadagni was an Italian prelate of the Discalced Carmelite order who served as the Bishop of Arezzo and later as a cardinal. Born in Florence in 1674 to a noble family, he pursued studies in civil and canon law before choosing a religious life. His ecclesiastical career advanced significantly following the election of his maternal uncle, Pope Clement XII, to the papacy. Throughout his life, he held several prominent positions within the Roman Curia, including serving as the Camerlengo of the Sacred College of Cardinals.