Ephraim of Antioch was a 6th-century presbyter who served as the Patriarch of Antioch from 527 until 545. Born in Amida, he was originally a high-ranking civil official and military general under the reigns of Emperors Anastasius and Justin I. After rebuilding Antioch following a devastating earthquake, he transitioned to monastic life and was eventually chosen by the people to lead the church. Known as a wonderworker, he was a staunch defender of the Council of Chalcedon and played a significant role in the theological disputes of the Byzantine era.