Anastasius I of Antioch was a 6th-century theologian and presbyter who served as the Patriarch of Antioch during two separate periods. Born in Palestine, he became a prominent religious leader within the Byzantine Empire. His tenure was marked by theological disputes, particularly his opposition to certain imperial doctrines regarding the Body of Christ favored by Emperor Justinian. Despite being deposed and exiled, he eventually regained his position in Antioch through the influence of Pope Gregory the Great.