Zofia of Słuck was a Polish-Lithuanian noblewoman and Orthodox saint born in 1585. As the final descendant of the Olelkowicz–Słucki family, she held the title of princess of Slutsk and Kopyl. Following a contentious marriage to Janusz Radziwiłł, she became a prominent defender of the Eastern Orthodox faith during a period of significant religious transition in the region. She died in 1612 at the age of 26, leaving a lasting impact on the religious landscape of her ancestral lands.