Grigorios of Antioch was a 6th-century prelate who served as the Eastern Orthodox Patriarch of Antioch between 571 and 593. Originally a monk in a Byzantine monastery in Jerusalem, he later served as an abbot in Sinai and Pharan. His tenure as patriarch was marked by significant political involvement, including mediating between Roman forces and the Persian King Chosroes II. Despite facing accusations of paganism and various legal challenges during his career, he remained an influential religious leader until his death.