Domitian of Melitene was a 6th-century Byzantine archbishop and a close relative of Emperor Maurice. Serving as the prelate of Melitene from approximately 580 until his death in Constantinople in 602, he acted as a significant diplomatic figure and a trusted advisor to the imperial throne. He is recognized as a saint by Chalcedonian churches for his efforts to uphold orthodoxy within the empire's northeastern territories. His life was marked by high-level political missions, including attempts to influence the Persian court during periods of civil unrest.