Macedonius II of Constantinople was a 6th-century prelate who served as the Ecumenical Patriarch of Constantinople from 496 to 511. A staunch defender of the Council of Chalcedon, he resisted intense pressure from Emperor Anastasius I to alter established church doctrines. Despite facing assassination attempts, public insults, and false accusations of heresy, he remained committed to the faith of the early Church Fathers. His refusal to compromise led to his forced removal from office and eventual death in exile.