Desiderius of Langres was a 4th-century bishop who served as the third prelate of Langres in Gaul. Born near Genoa, he was an active participant in several important ecclesiastical gatherings, including the Council of Sardica in 343 and the Council of Cologne in 346. He is remembered for his courageous attempt to intercede with the Vandals on behalf of his people, an action that ultimately led to his death during their invasions.